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AMINO ACIDS AND RELATED SUBSTANCES AGAINST CANCER: GLUTAMINE AND GLUTATHIONE
Glutamine
Glutamine is an amino acid best known for its function in decreasing
alcohol cravings. Glutamine is a versatile amino acid with a variety of
functions in fighting cancer. It improves the function of the immune
system by stimulating the growth of lymphocytes and phagocytes (the
immune army's warriors).
The role of glutamine in tumour cells has been studied extensively. A
number of new studies suggest that glutamine may be a potent cancer
therapy because it increases levels of the powerful antioxidant
glutathione. A study in the Annals of Surgery showed that glutamine may
increase the effectiveness of anti-tumour drugs by sensitizing cells to
chemotherapy. The Journal of Parenteral Enteral Nutrition reported that
glutamine decreases the rate of tumour growth by promoting activity of
natural killer cells. (Natural killer cells are often low in people with
cancer. These cells are able to kill certain types of cancer cells.)
Unlike other cells in our bodies, which require oxygen to live, tumour
cells are anaerobic and use glutamine as their fuel. To get the food
they need, tumours are equipped with glutamine traps, which literally
wait for glutamine to float by so they can grab it. If tumour cells
consistently sap our natural stores of glutamine, our body will run out
and the tumours will demand more. This causes muscle wasting. An obvious
solution is to supplement with glutamine to stop the wasting and
stimulate the body's natural killer cells. However, herein lays the
controversy: glutamine may actually promote tumour growth, as tumours
feed on glutamine among other nutrients. Despite glutamine's potential
role in alleviating the growth of tumour cells, the danger of the
opposite result leaves scientists wary. Still, the beneficial
possibilities warrant further research.
Glutamine is an essential amino acid to take while receiving
chemotherapy. Glutamine minimizes the damage caused by chemotherapy by:
• enhancing the repair of intestines during chemotherapy;
• repairing the damage chemotherapy does to the immune system;
• preventing many of the side-effects of chemotherapy treatment;
• enhancing the actions of chemotherapy - tumours may decrease in size
by 45 per cent if taking glutamine, compared to 25 per cent without
glutamine;
• increasing the survival rate of cancer patients receiving
chemotherapy;
• soothing and relieving the pain of and quickly healing sores in the
mouth (oral mucositis). Patients in a hospital in Boston, USA, receive
5000mg of glutamine six times daily to relieve these painful side
effects.
Glutathione
Glutathione is a tripeptide or protein produced in the liver from the
amino acids, cysteine, glutamic acid and glycine. It is a powerful
antioxidant and inhibits the formation of and protects against the
damage from free radicals. Glutathione defends the body against damage
from cigarette smoking, exposure to radiation, chemotherapy and toxins
such as alcohol. It is able to detoxify heavy metals and drugs, and aids
in the treatment of blood and liver diseases.
Glutathione guards against many forms of cancer and is similar in its
protective functions to beta-carotene. Glutathione protects cells by
neutralizing oxygen molecules before they harm cells.
Glutathione has the ability to protect the tissues of the arteries,
brain, heart, immune system, kidney, lenses of the eyes, liver, lungs
and skin against oxidative damage. Glutathione plays a role in
protecting against cancer and the effects of ageing. Older cells contain
20 to 30 per cent less glutathione than younger cells.
Red blood cell integrity and structure is improved with the use of this
handy amino acid. Glutathione detoxifies arsenic, aluminum, cadmium,
lead and mercury and inhibits the excess production of cytokines. It
facilitates the transport of essential nutrients to white blood cells
and protects white blood cells from damage.
Glutathione deactivates dangerous free radicals, making them harmless to
the body thereby helping to prevent the onset of cancer.
Good sources of glutathione include apples, grapefruit, spinach,
tomatoes and carrots.
*151/34/5*
CANCER
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